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This review utilizes national-level quantitative data to provide a comprehensive profile of how gender inequality impacts girls and boys, in low and middle income countries in the Pacific. This report describes the effects of gender inequality in the domains of health, education and transition to employment, protection and safe environment. The review identifies key data and knowledge gaps relating to gender inequality for children and adolescents, provides recommendations for priority gender indicators, and calls for investments in data collection, additional research and action to address the key drivers of gender inequality in the region.